General fact: 2221 is a number for which we're missing a fact (submit one to numbersapi at google mail!).
Mathematical fact: 2221 is a value of n for which s(n) is a repdigit.
Trivia: 2221 is an uninteresting number.
Historical date: January 29th is the day in 1941 that Alexandros Koryzis becomes Prime Minister of Greece upon the sudden death of his predecessor, dictator Ioannis Metaxas.